A reported binuclear Cu(II) complex of the type [Cu2(L1)2] [L1 = 2- Hydroxy-3-[(2-hydroxyethylimino)-methyl]-5-methyl-benzaldehyde] and another reported mononuclear Cu(II) complex [Cu(L2)2](ClO4)2 [L2 = 2-[(phenyl-pyridine-2-yl-methylene)-amino]-ethanol] were investigated for pH dependent catecholase activity in which 3,5-di-tertiary-butylcatechol was oxidized to 3,5-di-tert-butyl-obenzoquinone derivative, in methanol (MeOH) solvent. A comparison was made with reference to the turnover numbers for the catalytic activity in basic medium for the mononuclear and the dinuclear complexes.