In this review the importance of chirality in nature is highlighted considering the synthesis of enantiomerically pure compounds in the form of entioenriched amines which have immense pharmaceutical importance, Different strategies are considered here such as enantioselective reduction of imines, chiral pool approach, imine and enamide synthesis, stereoselective conversion of prochiral substrates to enantiopure compounds, enantioselective reduction of enamides, enantioselective imine reduction using organocatalyts and chiral auxiliary approach. Reductive amination is found to be an important strategy to synthesize chiral primary amines. The pros and cons of each strategies are discussed in this review in details. This will be helpful to researchers working in this field to design and plan their future activities which will benefit the society as a whole.